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A gene conversion hotspot in the human growth hormone (GH1) gene promoter.

Human mutation - 1 Feb 2009

Wolf Andreas, Millar David S, Caliebe Amke, Horan Martin, Newsway Vicky, Kumpf Dorothea, Steinmann Katharina, Chee Ik-Seung, Lee Young-Ho, Mutirangura Apiwat, Pepe Guglielmina, Rickards Olga, Schmidtke Jörg, Schempp Werner, Chuzhanova Nadia, Kehrer-Sawatzki Hildegard, Krawczak Michael, Cooper David N

Abstract excerpt

To assess the evolutionary importance of nonallelic (or interlocus) gene conversion for the highly polymorphic human growth hormone (GH1) gene promoter, sequence variation in this region was studied in four different ethnic groups. For 14 SNPs in the proximal GH1 promoter (535 bp), 60 different haplotypes were observed in 577 individuals (156 Britons, 116 Spaniards, 163 West-Africans, 142 Asians). Using a novel...

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PMID: 18800374
DOI: 10.1002/humu.20850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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