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Article

Minimal length requirement for proteasomal degradation of ubiquitin-dependent substrates.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2009

Verhoef Lisette G G C, Heinen Christian, Selivanova Alexandra, Halff Els F, Salomons Florian A, Dantuma Nico P

Abstract excerpt

An erroneous transcriptional process, known as molecular misreading, gives rise to an alternative transcript of the ubiquitin B (UBB) gene. This transcript encodes the protein UBB(+1), which comprises a ubiquitin moiety and a 19-aa C-terminal extension. UBB(+1) is found in affected neurons in neurodegenerative diseases and behaves as an atypical ubiquitin fusion degradation (UFD) proteasome substrate that is...

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Identifiers

PMID: 18796559
DOI: 10.1096/fj.08-115055

Genes

UBB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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