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Article

Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogaster.

Aging - 1 Mar 2011

Hoe Nicholas, Huang Chung M, Landis Gary, Verhage Marian, Ford Daniel, Yang Junsheng, van Leeuwen Fred W, Tower John

Abstract excerpt

Molecular Misreading (MM) is the inaccurate conversion of genomic information into aberrant proteins. For example, when RNA polymerase II transcribes a GAGAG motif it synthesizes at low frequency RNA with a two-base deletion. If the deletion occurs in a coding region, translation will result in production of misframed proteins. During mammalian aging, misframed versions of human amyloid precursor protein (hApp)...

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Identifiers

PMID: 21415465
DOI: 10.18632/aging.100278
PMCID: PMC3091519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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