Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the Transcriptional Corepressor Bcor in Embryonic Stem Cell Differentiation and Early Embryonic Development

29 Jul 2008

Abstract excerpt

Bcor (BCL6 corepressor) is a widely expressed gene that is mutated in patients with X-linked Oculofaciocardiodental (OFCD) syndrome. BCOR regulates gene expression in association with a complex of proteins capable of epigenetic modification of chromatin. These include Polycomb group (PcG) proteins, Skp-Cullin-F-box (SCF) ubiquitin ligase components and a Jumonji C (Jmjc) domain containing histone demethylase. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal Surgery and Treatments
Share to Neurogenesis and neuroplasticity mechanisms
Share to Retinal Development and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18795143
DOI: 10.1371/journal.pone.0002814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the Transcriptional Corepressor Bcor in Embryonic Stem Cell Differentiation and Early Embryonic DevelopmentPMID 18795143Read ↗

Polycomb Group and SCF Ubiquitin Ligases Are Found in a Novel BCOR Complex That Is Recruited to BCL6 TargetsSemantic proximity Read ↗

BCOR gene alterations in hematologic diseases.Semantic proximity Read ↗

BCOR regulates mesenchymal stem cell function by epigenetic mechanisms.Semantic proximity Read ↗

Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR.Semantic proximity Read ↗

BCOR analysis in patients with OFCD and Lenz microphthalmia syndromes, mental retardation with ocular anomalies, and cardiac laterality defects.Semantic proximity Read ↗

Bcor insufficiency promotes initiation and progression of myelodysplastic syndromeSemantic proximity Read ↗

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesisSemantic proximity Read ↗

Analysis of a BCOR internal tandem duplication in mouse embryonic stem cell to neuronal precursor differentiation.Semantic proximity Read ↗

OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the Polycomb-group repressive complex 1.1 (PRC1.1) gene BCORSemantic proximity Read ↗

Novel mutations in BCOR in three patients with oculo-facio-cardio-dental syndrome, but none in Lenz microphthalmia syndrome.Semantic proximity Read ↗

Clarifying the Impact of Polycomb Complex Component Disruption in Human CancersSemantic proximity Read ↗

A family of oculofaciocardiodental syndrome (OFCD) with a novel BCOR mutation and genomic rearrangements involving NHS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.