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Article

The tight junction protein CAR regulates cardiac conduction and cell-cell communication.

The Journal of experimental medicine - 29 Sept 2008

Lisewski Ulrike, Shi Yu, Wrackmeyer Uta, Fischer Robert, Chen Chen, Schirdewan Alexander, Jüttner Rene, Rathjen Fritz, Poller Wolfgang, Radke Michael H, Gotthardt Michael

Abstract excerpt

The Coxsackievirus-adenovirus receptor (CAR) is known for its role in virus uptake and as a protein of the tight junction. It is predominantly expressed in the developing brain and heart and reinduced upon cardiac remodeling in heart disease. So far, the physiological functions of CAR in the adult heart are largely unknown. We have generated a heart-specific inducible CAR knockout (KO) and found impaired...

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Identifiers

PMID: 18794341
DOI: 10.1084/jem.20080897
PMCID: PMC2556793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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