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Article

Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2000

Gong J, Avigan D, Chen D, Wu Z, Koido S, Kashiwaba M, Kufe D

Abstract excerpt

We have reported that fusions of murine dendritic cells (DCs) and murine carcinoma cells reverse unresponsiveness to tumor-associated antigens and induce the rejection of established metastases. In the present study, fusions were generated with primary human breast carcinoma cells and autologous DCs. Fusion cells coexpressed tumor-associated antigens and DC-derived costimulatory molecules. The fusion cells also...

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Identifiers

PMID: 10688917
DOI: 10.1073/pnas.050587197
PMCID: PMC15995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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