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Article

Regulation of<i>KEAP1</i>expression by promoter methylation in malignant gliomas and association with patient’s outcome

1 Mar 2011

Abstract excerpt

In light with the view that KEAP1 loss of function may impact tumour behavior and modify response to chemotherapeutical agents, we sought to determine whether KEAP1 gene is epigenetically regulated in malignant gliomas. We developed a Quantitative Methylation Specific PCR (QMSP) assay to analyze 86 malignant gliomas and 20 normal brain tissues. The discriminatory power of the assay was assessed by Receiving...

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Share to Epigenetics and DNA Methylation
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PMID: 21173573
DOI: 10.4161/epi.6.3.14408

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