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Article

Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation<i>via</i>inhibition of JAK3/STAT3 signaling

1 Jan 2011

Abstract excerpt

Persistently activated JAK/STAT3 signaling pathway plays a pivotal role in various human cancers including major carcinomas and hematologic tumors, and is implicated in cancer cell survival and proliferation. Therefore, inhibition of JAK/STAT3 signaling may be a clinical application in cancer therapy. Here, we report that 2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo [1,3]oxathiol-4-one (BOT-4-one), a small...

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Identifiers

PMID: 21499010
DOI: 10.3858/emm.2011.43.5.035

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