Article
Generating SNP barcode to evaluate SNP-SNP interaction of disease by particle swarm optimization.
Computational biology and chemistry - 1 Feb 2009
Chang Hsueh-Wei, Yang Cheng-Hong, Ho Chang-Hsuan, Wen Cheng-Hao, Chuang Li-Yeh
Abstract excerpt
Genome-wide association analysis involved many single-nucleotide polymorphisms (SNPs) data is challenging mathematically and computationally. Hence, we propose the odds ratio-based discrete binary particle swarm optimization (OR-DBPSO) method that uses the OR as a new quantitative measure of disease risk among many SNP combinations with genotypes called "SNP barcode". DBPSO are applied to generate SNP barcode,...
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