Article
Particle swarm optimization algorithm for analyzing SNP-SNP interaction of renin-angiotensin system genes against hypertension.
Molecular biology reports - 1 Jul 2013
Wu Shyh-Jong, Chuang Li-Yeh, Lin Yu-Da, Ho Wen-Hsien, Chiang Fu-Tien, Yang Cheng-Hong, Chang Hsueh-Wei
Abstract excerpt
Most non-significant individual single nucleotide polymorphisms (SNPs) were undiscovered in hypertension association studies. Their possible SNP-SNP interactions were usually ignored and leaded to missing heritability. In present study, we proposed a particle swarm optimization (PSO) algorithm to analyze the SNP-SNP interaction associated with hypertension. Genotype dataset of eight SNPs of renin-angiotensin...
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