Article
Single nucleotide polymorphism barcoding to evaluate oral cancer risk using odds ratio-based genetic algorithms.
The Kaohsiung journal of medical sciences - 1 Jul 2012
Yang Cheng-Hong, Chuang Li-Yeh, Cheng Yu-Huei, Lin Yu-Da, Wang Chun-Lin, Wen Cheng-Hao, Chang Hsueh-Wei
Abstract excerpt
Cancers often involve the synergistic effects of gene-gene interactions, but identifying these interactions remains challenging. Here, we present an odds ratio-based genetic algorithm (OR-GA) that is able to solve the problems associated with the simultaneous analysis of multiple independent single nucleotide polymorphisms (SNPs) that are associated with oral cancer. The SNP interactions between four SNPs-namely...
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