Article
Chaotic particle swarm optimization for detecting SNP-SNP interactions for CXCL12-related genes in breast cancer prevention.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Jul 2012
Chuang Li-Yeh, Chang Hsueh-Wei, Lin Ming-Cheng, Yang Cheng-Hong
Abstract excerpt
Genome-wide association studies have revealed that many single nucleotide polymorphisms (SNPs) are associated with breast cancer, and yet the potential SNP-SNP interactions have not been well addressed to date. This study aims to develop a methodology for the selection of SNP-genotype combinations with a maximum difference between case and control groups. We propose a new chaotic particle swarm optimization...
Topics
- Adult
- Algorithms
- Breast Neoplasms
- Calibration
- Carcinoma
- Chemokine CXCL12
- Disease Progression
- Epistasis, Genetic
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans
- Middle Aged