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Article

Genetic diversity of Group A Streptococcus M protein: implications for typing and vaccine development.

Vaccine - 29 Oct 2008

Smeesters Pierre R, Mardulyn Patrick, Vergison Anne, Leplae Raphaël, Van Melderen Laurence

Abstract excerpt

Group A Streptococci (GAS) are classified into 180 emm-types based on the sequence of the amino-terminal hyper-variable region of the M surface protein. The genetic relatedness of the whole surface-exposed part of M was investigated in well-characterized Belgian and Brazilian GAS isolates which belong to different epidemiological and clinical landscapes. Despite a small number of different emm-types and an...

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PMID: 18789365
DOI: 10.1016/j.vaccine.2008.08.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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