Article
Simulating calcium influx and free calcium concentrations in yeast.
Cell calcium - 1 Feb 2009
Cui Jiangjun, Kaandorp Jaap A, Ositelu Olufisayo O, Beaudry Veronica, Knight Alicia, Nanfack Yves F, Cunningham Kyle W
Abstract excerpt
Yeast can proliferate in environments containing very high Ca(2+) primarily due to the activity of vacuolar Ca(2+) transporters Pmc1 and Vcx1. Yeast mutants lacking these transporters fail to grow in high Ca(2+) environments, but growth can be restored by small increases in environmental Mg(2+). Low extracellular Mg(2+) appeared to competitively inhibit novel Ca(2+) influx pathways and to diminish the...
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