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Article

Association between polymorphisms in DNA base excision repair genes XRCC1, APE1, and ADPRT and differentiated thyroid carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2008

Chiang Feng-Yu, Wu Che-Wei, Hsiao Pi-Jung, Kuo Wen-Rei, Lee Ka-Wo, Lin Jen-Chih, Liao Yi-Chu, Juo Suh-Hang Hank

Abstract excerpt

PURPOSE: DNA BER pathway is related with carcinogenesis. We hypothesized that functional polymorphisms of three BER genes, XRCC1, apurinic/apyrimidinic endonuclease (APE1), and ADPRT, confer risks for DTC and its progression. EXPERIMENTAL DESIGN: Five common nonsynonymous single nucleotide polymorphisms (Arg194Trp, Arg280His, and Arg399Gln for XRCC1; Asp148Glu for APE1; and Val762Ala for ADPRT) were genotyped in...

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Source

Identifiers

PMID: 18779313
DOI: 10.1158/1078-0432.CCR-08-0906

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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