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Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention.

Molecular cancer therapeutics - 1 Sept 2008

Chiu Ching-Chi, Lin Chien-Yu, Lee Li-Yu, Chen Yin-Ju, Kuo Ting-Fang, Chang Joseph Tung-Chieh, Liao Chun-Ta, Wang Hung-Ming, Yen Tzu-Chen, Shen Chia-Rui, Liao Shuen-Kuei, Cheng Ann-Joy

Abstract excerpt

Glucose-regulated protein 78 (Grp78) is an endoplasmic reticulum chaperone protein and is overexpressed in various cancers. However, it is unclear how significance of this molecule play an active role contributing to the oncogenic effect of head and neck cancer (HNC). To investigate the potential function of Grp78, six HNC cell lines were used. We found that Grp78 is highly expressed in all six cell lines and...

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Identifiers

PMID: 18790759
DOI: 10.1158/1535-7163.MCT-08-0172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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