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Article

Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations.

Bioscience, biotechnology, and biochemistry - 1 Sept 2008

Ozaki Shin-Ichi, Inada Atsushi, Sada Kazuya

Abstract excerpt

Human cystathionine beta-synthase (CBS) catalyzes a pyridoxal 5'-phosphate (PLP) dependent beta-replacement reaction to synthesize cystathionine from serine and homocysteine. The enzyme is unique in bearing not only a catalytically important PLP but also heme. In order to study a regulatory process mediated by heme, we performed mutagenesis of Arg-51 and Arg-224, which have hydrogen-bonding interactions with...

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Identifiers

PMID: 18776696
DOI: 10.1271/bbb.80231

Genes

CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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