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Article

Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase.

Biochemistry - 9 Apr 2002

Ojha Sunil, Wu Jianmin, LoBrutto Russell, Banerjee Ruma

Abstract excerpt

Human cystathionine beta-synthase is a hemeprotein that catalyzes a pyridoxal phosphate (PLP)-dependent condensation of serine and homocysteine into cystathionine. Biophysical characterization of this enzyme has led to the assignment of the heme ligands as histidine and cysteinate, respectively, which has recently been confirmed by crystal structure determination of the catalytic core of the protein. Using...

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PMID: 11926827
DOI: 10.1021/bi011827o

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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