Article
Protective activity and immunogenicity of two recombinant anthrax vaccines for veterinary use.
Vaccine - 23 Oct 2008
Fasanella A, Tonello F, Garofolo G, Muraro L, Carattoli A, Adone R, Montecucco C
Abstract excerpt
In this study, the efficacy of two experimental vaccines against Bacillus anthracis toxinaemia was evaluated in the rabbit model. A recombinant Protective Antigen (rPA) mutant and a trivalent vaccine (TV) composed by the rPA, a inactive mutant of Lethal Factor (mLF-Y728A; E735A) and a inactive mutant of Edema Factor (mEF-K346R), both emulsified with mineral oils, were evaluated for their immunogenicity and...
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