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Article

Identification of genes for mycothiol biosynthesis in Streptomyces coelicolor A3(2).

Journal of microbiology (Seoul, Korea) - 1 Feb 2006

Park Joo-Hong, Cha Chang-Jun, Roe Jung-Hye

Abstract excerpt

Mycothiol is a low molecular weight thiol compound produced by a number of actinomycetes, and has been suggested to serve both anti-oxidative and detoxifying roles. To investigate the metabolism and the role of mycothiol in Streptomyces coelicolor, the biosynthetic genes (mshA, B, C, and D) were predicted based on sequence homology with the mycobacterial genes and confirmed experimentally. Disruption of the mshA,...

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PMID: 16554727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Identification of genes for mycothiol biosynthesis in Streptomyces coelicolor A3(2).PMID 16554727Read ↗

Mycothiol regulates and is regulated by a thiol-specific antisigma factor RsrA and sigma(R) in Streptomyces coelicolor.Semantic proximity Read ↗

Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria.Semantic proximity Read ↗

Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes.Semantic proximity Read ↗

Mining of a streptothricin gene cluster from Streptomyces sp. TP-A0356 genome via heterologous expression.Semantic proximity Read ↗

Identification of a monooxygenase from Streptomyces coelicolor A3(2) involved in biosynthesis of actinorhodin: purification and characterization of the recombinant enzyme.Semantic proximity Read ↗

Novel genes that influence development in Streptomyces coelicolor.Semantic proximity Read ↗

N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis.Semantic proximity Read ↗

ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize gamma-butyrolactones.Semantic proximity Read ↗

The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).Semantic proximity Read ↗

Cloning and characterization of a gene (msdA) encoding methylmalonic acid semialdehyde dehydrogenase from Streptomyces coelicolor.Semantic proximity Read ↗

Role of an essential acyl coenzyme A carboxylase in the primary and secondary metabolism of Streptomyces coelicolor A3(2).Semantic proximity Read ↗

Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.Semantic proximity Read ↗

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