Article
Hypoxia and leucine deprivation induce human insulin-like growth factor binding protein-1 hyperphosphorylation and increase its biological activity.
Endocrinology - 1 Jan 2009
Seferovic Maxim D, Ali Rashad, Kamei Hiroyasu, Liu Suya, Khosravi Javad M, Nazarian Steven, Han Victor K M, Duan Cunming, Gupta Madhulika B
Abstract excerpt
Fetal growth restriction is often caused by uteroplacental insufficiency that leads to fetal hypoxia and nutrient deprivation. Elevated IGF binding protein (IGFBP)-1 expression associated with fetal growth restriction has been documented. In this study we tested the hypothesis that hypoxia and nutrient deprivation induce IGFBP-1 phosphorylation and increase its biological potency in inhibiting IGF actions. HepG2...
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