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Article

N-acetylcholinesterase-induced apoptosis in Alzheimer's disease.

PloS one - 1 Sept 2008

Toiber Debra, Berson Amit, Greenberg David, Melamed-Book Naomi, Diamant Sophia, Soreq Hermona

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) involves loss of cholinergic neurons and Tau protein hyper-phosphorylation. Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena. METHODOLOGY AND PRINCIPA...

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Source

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Identifiers

PMID: 18769671
DOI: 10.1371/journal.pone.0003108
PMCID: PMC2518620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18769671-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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