Article
In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease.
Journal of neuropathology and experimental neurology - 1 Sept 1999
Selznick L A, Holtzman D M, Han B H, Gökden M, Srinivasan A N, Johnson E M, Roth K A
Abstract excerpt
The mechanism by which cells die in Alzheimer disease (AD) is unknown. Several investigators speculate that much of the cell loss may be due to apoptosis, a highly regulated form of programmed cell death. Caspase-3 is a critical effector of neuronal apoptosis and may be inappropriately activated in AD. To address this possibility, we examined cortical and hippocampal brain sections from AD patients, as well as 2...
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