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Article

A sensitive functional assay reveals frequent loss of genomic imprinting in human placenta.

Epigenetics - 1 Sept 2008

Lambertini Luca, Diplas Andreas I, Lee Men-Jean, Sperling Rhoda, Chen Jia, Wetmur James

Abstract excerpt

Loss of imprinting (LOI) is the gain of expression from the silent allele of an imprinted gene normally expressed from only one parental copy. LOI has been associated with neurodevelopmental disorders and reproductive abnormalities. The mechanisms of imprinting are varied, with DNA methylation re...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18769151
DOI: 10.4161/epi.3.5.6755
PMCID: PMC2714257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18769151-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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