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Hepatitis C Virus Core Protein Augments Androgen Receptor-Mediated Signaling

4 Sept 2008

Abstract excerpt

Hepatitis C virus (HCV) infection is frequently associated with the development of hepatocellular carcinoma (HCC), which is one of the male-dominant diseases. Androgen signaling in liver may be related to carcinogenesis. In this study, we investigated whether HCV proteins cross talk with the androgen receptor (AR) signaling pathway for promotion of carcinogenesis. We have demonstrated that HCV core protein alone...

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PMID: 18768969
DOI: 10.1128/jvi.01300-08

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