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Article

The molecular mechanism of Vav3 oncogene on upregulation of androgen receptor activity in prostate cancer cells

25 Jan 2010

Abstract excerpt

Our previous studies revealed that Vav3 oncogene is overexpressed in human prostate cancer, enhances androgen receptor (AR)-mediated signaling, and may play a role in prostate cancer development and progression. The purpose of this study was to determine the molecular mechanisms responsible for AR activation by Vav3. We found that interaction between N-terminus and C-terminus of AR is essential for its elevated...

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Share to Estrogen and related hormone effects
Share to PI3K/AKT/mTOR signaling in cancer
Share to Prostate Cancer Treatment and Research

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PMID: 20126983
DOI: 10.3892/ijo_00000538

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