Article
Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.
The Journal of biological chemistry - 31 Oct 2008
Fluhrer Regina, Fukumori Akio, Martin Lucas, Grammer Gudula, Haug-Kröper Martina, Klier Bärbel, Winkler Edith, Kremmer Elisabeth, Condron Margaret M, Teplow David B, Steiner Harald, Haass Christian
Abstract excerpt
More than 150 familial Alzheimer disease (FAD)-associated missense mutations in presenilins (PS1 and PS2), the catalytic subunit of the gamma-secretase complex, cause aberrant amyloid beta-peptide (Abeta) production, by increasing the relative production of the highly amyloidogenic 42-amino acid variant. The molecular mechanism behind this pathological activity is unclear, and different possibilities ranging from...
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