Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of CYP27B1, encoding 25-hydroxyvitamin D-1alpha-hydroxylase, as a candidate tumor suppressor gene in primary and severe secondary/tertiary hyperparathyroidism.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2009

Lauter Kelly, Arnold Andrew

Abstract excerpt

CYP27B1, encoding 25-hydroxyvitamin D-1alpha-hydroxylase, converts 25-hydroxyvitamin D to its active form, 1,25-dihydroxyvitamin D, and is expressed primarily in the kidney but also in nontraditional sites including the parathyroid glands. Whereas the role of locally produced 1,25-dihydroxyvitamin D is not yet clear, it is possible that it contributes importantly to vitamin D-mediated inhibition of parathyroid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Share to Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Binding Sites

Share to Genes, Tumor Suppressor

Share to Hyperparathyroidism

Share to Parathyroid Neoplasms

Share to Receptors, Calcitriol

Source

Open in PubMed Open full text

Identifiers

PMID: 18767934
DOI: 10.1359/jbmr.080903
PMCID: PMC2689078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of CYP27B1, encoding 25-hydroxyvitamin D-1alpha-hydroxylase, as a candidate tumor suppressor gene in primary and severe secondary/tertiary hyperparathyroidism.PMID 18767934Read ↗

Mutational analysis of CDKN1B, a candidate tumor-suppressor gene, in refractory secondary/tertiary hyperparathyroidism.Semantic proximity Read ↗

Parathyroid cancer.Semantic proximity Read ↗

Splice Variants of the CYP27b1 Gene and the Regulation of 1,25-Dihydroxyvitamin D3 ProductionSemantic proximity Read ↗

Novel CYP27B1 Gene Mutations in Patients with Vitamin D-Dependent Rickets Type 1A.Semantic proximity Read ↗

Mutational analysis of the extracellular Ca(2+)-sensing receptor gene in human parathyroid tumors.Semantic proximity Read ↗

Human 25-hydroxyvitamin D-1alpha-hydroxylase: cloning, mutations, and gene expression.Semantic proximity Read ↗

Vitamin D receptor as a candidate tumor-suppressor gene in severe hyperparathyroidism of uremia.Semantic proximity Read ↗

RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cellsSemantic proximity Read ↗

Immunohistochemistry of cyclin D1 and beta-catenin, and mutational analysis of exon 3 of beta-catenin gene in parathyroid adenomas.Semantic proximity Read ↗

Mutational analysis of the vitamin D receptor does not support its candidacy as a tumor suppressor gene in parathyroid adenomas.Semantic proximity Read ↗

The vitamin D receptor (VDR) start codon polymorphism in primary hyperparathyroidism and parathyroid VDR messenger ribonucleic acid levels.Semantic proximity Read ↗

Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.