Article
Vitamin D receptor as a candidate tumor-suppressor gene in severe hyperparathyroidism of uremia.
The Journal of clinical endocrinology and metabolism - 1 Feb 2000
Brown S B, Brierley T T, Palanisamy N, Salusky I B, Goodman W, Brandi M L, Drüeke T B, Sarfati E, Ureña P, Chaganti R S, Pike J W, Arnold A
Abstract excerpt
Most chronic renal failure patients with severe refractory hyperparathyroidism harbor at least one monoclonal parathyroid tumor, but the specific acquired genetic defects that confer this clonal selective advantage remain poorly understood. Somatic inactivation of the vitamin D receptor (VDR) gene could contribute to clonal outgrowth, because a parathyroid cell containing this lesion would have an impaired...
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