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Article

Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.

Journal of cell science - 1 Oct 2008

Webb Tom R, Cross Sally H, McKie Lisa, Edgar Ruth, Vizor Lucie, Harrison Jackie, Peters Jo, Jackson Ian J

Abstract excerpt

The intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the translation elongation factor, eEF2 (also known as EFT1). This enigmatic modification occurs in all eukaryotes and is produced in yeast by the action of five gene products, DPH1 to DPH5. Sequence homologues of these genes are present in all sequenced eukaryotic genomes and, in higher eukaryotes, there is functional...

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Source

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Identifiers

PMID: 18765564
DOI: 10.1242/jcs.035550
PMCID: PMC2592597

Genes

DPH1
DPH2
DPH3
DPH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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