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Article

Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

1 Sept 2008

Abstract excerpt

Alterations in the composition of intestinal commensal bacteria are associated with enhanced susceptibility to multiple inflammatory diseases, including those conditions associated with interleukin (IL)-17-producing CD4(+) T helper (Th17) cells. However, the relationship between commensal bacteria and the expression of proinflammatory cytokines remains unclear. Using germ-free mice, we show that the frequency of...

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PMID: 18762568
DOI: 10.1084/jem.20080720

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