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IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic

13 Apr 2013

Abstract excerpt

IL-22 is a good candidate to play a critical role in regulating gut microbiota because it is an important inducer of antimicrobial peptides and mucins in the gut. However, whether IL-22 participates in immune homeostasis by way of modulating gut microbiota remains to be elucidated. In this study, we find, through 16S rRNA gene-pyrosequencing analysis, that healthy IL-22-deficient mice had altered colonic...

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PMID: 23585682
DOI: 10.4049/jimmunol.1300016

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