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Article

The APP670/671 mutation alters calcium signaling and response to hyperosmotic stress in rat primary hippocampal neurons.

Neuroscience letters - 31 Oct 2008

Kloskowska Ewa, Bruton Joseph D, Winblad Bengt, Benedikz Eirikur

Abstract excerpt

Altered calcium homeostasis is implicated in the pathogenesis of Alzheimer's disease and much effort has been put into understanding the association between the autosomal dominant gene mutations causative of this devastating disease and perturbed calcium signaling. We have focused our attention on the effect of the APP670/671 mutation on spontaneous calcium oscillations in embryonic hippocampal neurons derived...

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PMID: 18761056
DOI: 10.1016/j.neulet.2008.08.051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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