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Article

Automated screening of C. elegans neurodegeneration mutants enabled by microfluidics and image analysis algorithms.

Integrative biology : quantitative biosciences from nano to macro - 17 Sept 2018

de Carlos Cáceres Ivan, Porto Daniel A, Gallotta Ivan, Santonicola Pamela, Rodríguez-Cordero Josue, Di Schiavi Elia, Lu Hang

Abstract excerpt

Spinal muscular atrophy (SMA) is a degenerative disorder that selectively deteriorates motor neurons due to a deficiency of survival motor neuron protein (SMN). The illness is the leading genetic cause of death in infants and is difficult to study in complex biological systems such as humans. A simpler model system, such as the nematode C. elegans, can be used to study potential mechanisms underlying this...

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Identifiers

PMID: 30116818
DOI: 10.1039/c8ib00091c
PMCID: PMC6193809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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