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Notch-1 regulates transcription of the epidermal growth factor receptor through p53

20 Mar 2008

Abstract excerpt

The Notch pathway plays a key role in the development and is increasingly recognized for its importance in cancer. We demonstrated previously the overexpression of Notch-1 and its ligands in gliomas and showed that their knockdown inhibits glioma cell proliferation and survival. To elucidate the mechanisms downstream of Notch-1 in glioma cells, we performed microarray profiling of glioma cells transfected with...

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PMID: 18359760
DOI: 10.1093/carcin/bgn079

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