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Article

Response of Ewing tumor cells to forced and activated p53 expression.

Oncogene - 22 May 2003

Kovar Heinrich, Pospisilova Sarka, Jug Gunhild, Printz Dieter, Gadner Helmut

Abstract excerpt

The EWS-FLI1 transcription factor is consistently expressed in 85% of Ewing tumors (EFT). In heterologous cells, EWS-FLI1 induces p53-dependent cell cycle arrest or apoptosis. It has been speculated that the p53 tumor suppressor pathway may be generally compromised in EFT despite only rare p53 mu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12761489
DOI: 10.1038/sj.onc.1206391

Genes

FLI1
APAF1
BAX
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12761489-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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