Sorted-cell proteomics reveals an AT1-associated epithelial cornification phenotype and suggests endothelial redox imbalance in human bronchopulmonary dysplasia.

doi:10.1152/ajplung.00098.2025

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Article

Sorted-cell proteomics reveals an AT1-associated epithelial cornification phenotype and suggests endothelial redox imbalance in human bronchopulmonary dysplasia.

American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2025

Ushakumary Mereena George, Chrisler William B, Bandyopadhyay Gautam, Huyck Heidie, Gorman Brittney L, Beishembieva Naina, Pitonzo Ariana, Lai Zhenli J, Fillmore Thomas L, Attah Isaac Kwame, Deutsch Gail, Purkerson Jeffrey M, Dylag Andrew M, Misra Ravi S, Carson James P, Adkins Joshua N, Pryhuber Gloria S, Clair Geremy C

Abstract excerpt

Bronchopulmonary dysplasia (BPD) is a neonatal lung disease characterized by inflammation and scarring leading to long-term tissue damage. Previous whole tissue proteomics identified BPD-specific proteome changes and cell type shifts. Little is known about the proteome-level changes within specific cell populations in disease. Here, we sorted epithelial (EPI) and endothelial (ENDO) cell populations based on their...

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PMID: 40960949
DOI: 10.1152/ajplung.00098.2025

Genes

LMO7
SCEL

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