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Article

ACTN3 genotype in professional endurance cyclists.

International journal of sports medicine - 1 Nov 2006

Lucia A, Gómez-Gallego F, Santiago C, Bandrés F, Earnest C, Rabadán M, Alonso J M, Hoyos J, Córdova A, Villa G, Foster C

Abstract excerpt

The Z-disk protein alpha-actinin-3 is only expressed in type II muscle fibres, which are responsible for generating forceful contractions at high velocity. Despite the evolutionary conservation of alpha-actinin-3, approximately one in every five Caucasians of European ancestry is totally deficient in this protein, due to homozygosity for a R577X polymorphism in the ACTN3 gene. This, together with the results of...

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Actinin
Analysis of Variance
Case-Control Studies
Chi-Square Distribution
Nucleic Acid Amplification Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Physical Endurance

Pulmonary Ventilation

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Identifiers

PMID: 16612741
DOI: 10.1055/s-2006-923862

Genes

ACTN3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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ACTN3 genotype in professional endurance cyclists.PMID 16612741Read ↗

ACTN3 genotype is associated with muscle phenotypes in women across the adult age span.Semantic proximity Read ↗

Genotype Distribution of the ACTN3 p.R577X Polymorphism in Elite Badminton Players: A Preliminary Study.Semantic proximity Read ↗

Are 'endurance' alleles 'survival' alleles? Insights from the ACTN3 R577X polymorphism.Semantic proximity Read ↗

Association of the ACTN3 R577X polymorphism with power athlete status in Russians.Semantic proximity Read ↗

Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes.Semantic proximity Read ↗

Association between the ACTN3 R577X polymorphism and female endurance athletes in China.Semantic proximity Read ↗

Association between the ACTN3 R577X polymorphism and artistic gymnastic performance in Italy.Semantic proximity Read ↗

ACTN3 R577X and other polymorphisms are not associated with elite endurance athlete status in the Genathlete study.Semantic proximity Read ↗

The ACTN3 R577X polymorphism in Russian endurance athletes.Semantic proximity Read ↗

ACTN3 genotype influences exercise-induced muscle damage during a marathon competition.Semantic proximity Read ↗

ACTN3 genotype and modulation of skeletal muscle response to exercise in human subjects.Semantic proximity Read ↗

The Effect of Heterozygosity for the ACTN3 Null Allele on Human Muscle Performance.Semantic proximity Read ↗

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