Article
Transplacental transfer of genotoxins and transplacental carcinogenesis.
Environmental health perspectives - 1 Jul 1993
Autrup H
Abstract excerpt
A number of chemical compounds induce cancer in the offspring of animals treated with these compounds. The fetus is sensitive to the toxic and teratogenic effects of chemicals in the early embryonic stages, whereas it is sensitive to carcinogenic effects during late fetal stages. Carcinogens may be direct acting or may require metabolic oxidation such as those in tobacco smoke. Activation can occur in utero....
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