Article
Effect of androgen insensitivity on diabetogenesis in db/db male mice with testicular feminization (Tfm).
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Apr 1991
Prochazka M, Leiter E H
Abstract excerpt
In C3H mice, a major component of susceptibility to the diabetogenic action of an obesity mutation (diabetes, db) is male gender associated. We tested whether increased male susceptibility was an androgen receptor mediated process. C3H.SW/Lt-derived db/db males were rendered androgen-receptor function-deficient by introducing the testicular feminization (Tfm) mutation of the X-linked androgen receptor gene. The...
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