Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel delta 0 mutation in cis with Hb Knossos: a study of different genetic interactions in three Egyptian families.

British journal of haematology - 1 Jul 1991

Olds R J, Sura T, Jackson B, Wonke B, Hoffbrand A V, Thein S L

Abstract excerpt

We have defined the molecular basis of normal HbA2 beta-thalassaemia associated with Hb Knossos. DNA sequence analysis of the delta globin gene in cis with beta Knossos showed deletion of a single A in codon 59 leading to a premature termination at codon 60. This delta 0/beta Knossos allele has been observed in three unrelated Egyptian families and associated with a single beta haplotype (+----++). One individual...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Share to Restriction Mapping

Source

Identifiers

PMID: 1873227
DOI: 10.1111/j.1365-2141.1991.tb04460.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel delta 0 mutation in cis with Hb Knossos: a study of different genetic interactions in three Egyptian families.PMID 1873227Read ↗

A 65 bp duplication/insertion in exon II of the beta globin gene causing beta0-thalassemia.Semantic proximity Read ↗

δ0-Thalassemia in cis of βKnossos globin gene: first homozygous description in thalassemia intermedia Libyans and first combination with codon 39 (C→T) in thalassemia intermedia Tunisian patients.Semantic proximity Read ↗

Novel α-Globin Splice Site Mutation (HBA2: c.96-5C>A) in Combination with Three-Gene Deletion Hb H Disease.Semantic proximity Read ↗

Combination of Hb Knossos [Cod 27 (G-T)] and IVSII-745 (C-G) in a Turkish patient with beta-thalassemia major.Semantic proximity Read ↗

A novel beta-globin variant: Hb Poços de Caldas [beta 61(E5)Lys-->Gln].Semantic proximity Read ↗

Hb Johnstown [beta 109 (G11) Val-->Leu]: second case described and associated for the first time with beta(0)-thalassemia in two Spanish families.Semantic proximity Read ↗

Hb Iraq-Halabja beta10 (A7) Ala-->Val (GCC-->GTC): a new beta-chain silent variant in a family with multiple Hb disorders.Semantic proximity Read ↗

Eight-base deletion in exon 3 of the beta-globin gene produced a novel variant (beta khon kaen) with an inclusion body beta-thalassemia trait.Semantic proximity Read ↗

Haplotype analysis of two new, independent cases of Hb Osu-Christiansborg.Semantic proximity Read ↗

Association of a novel high oxygen affinity haemoglobin variant with delta beta thalassaemia.Semantic proximity Read ↗

Severe thalassaemia intermedia caused by interaction of homozygosity for alpha-globin gene triplication with heterozygosity for beta zero-thalassaemia.Semantic proximity Read ↗

Identification of a novel beta O-thalassaemia mutation in a Greek family and subsequent prenatal diagnosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.