A novel delta 0 mutation in cis with Hb Knossos: a study of different genetic interactions in three Egyptian families.

doi:10.1111/j.1365-2141.1991.tb04460.x

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Article

A novel delta 0 mutation in cis with Hb Knossos: a study of different genetic interactions in three Egyptian families.

British journal of haematology - 1 Jul 1991

Olds R J, Sura T, Jackson B, Wonke B, Hoffbrand A V, Thein S L

Abstract excerpt

We have defined the molecular basis of normal HbA2 beta-thalassaemia associated with Hb Knossos. DNA sequence analysis of the delta globin gene in cis with beta Knossos showed deletion of a single A in codon 59 leading to a premature termination at codon 60. This delta 0/beta Knossos allele has b...

Topics

Adult
Alleles
Base Sequence
DNA
Egypt
Female
Gene Amplification
Globins
Hemoglobins, Abnormal
Humans
Male
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Restriction Mapping
Thalassemia

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