Article
δ0-Thalassemia in cis of βKnossos globin gene: first homozygous description in thalassemia intermedia Libyans and first combination with codon 39 (C→T) in thalassemia intermedia Tunisian patients.
Clinical chemistry and laboratory medicine - 1 Oct 2012
Sahli Chaima Abdelhafidh, Bibi Amina, Ouali Faida, Siala Hajer, Fredj Sondess Hadj, Othmani Rym, Ouenniche Fekria, Cheour Mondher, Fitouri Zohra, Becher Saida Ben, Messaoud Taieb
Abstract excerpt
BACKGROUND: β-Thalassemia is the most common disease among hemoglobinopathies in North African and Arab populations. In the present study we report the first description of the β-Knossos codon27 (G→T) (βKnossos) allele in cis with the δ059 (-A) mutation in thalassemia intermedia patients in Tunisia and Libya. METHODS: This identification was carried out by sequencing analysis of the whole coding regions of the δ-...
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