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Article

Hb Johnstown [beta 109 (G11) Val-->Leu]: second case described and associated for the first time with beta(0)-thalassemia in two Spanish families.

American journal of hematology - 1 Dec 2000

Ropero P, Villegas A, González A F, Anguita E, Sánchez J, Carreño D L, Arrizabalaga B, Atuxta L

Abstract excerpt

Hb Johnstown, a high oxygen affinity hemoglobin, was identified in four members from two unrelated Spanish families with erythrocytosis and left-shifted hemoglobin-oxygen dissociation curve. This hemoglobin variant, electrophoretically silent, was analyzed by reverse-phase high-performance liquid chromatography, and the mutation was characterized at the DNA level by beta gene sequencing. In one of these families,...

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Identifiers

PMID: 11074558
DOI: 10.1002/1096-8652(200012)65:4<298::aid-ajh8>3.0.co;2-k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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