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Article

Abnormal structure and co-operative binding of low-density lipoprotein receptors containing the Glu-80-->Lys mutation.

Biochimica et biophysica acta - 6 Apr 1995

Patel D D, Soutar A K, Knight B L

Abstract excerpt

The properties of low-density lipoprotein (LDL) receptors containing a Glu to Lys substitution at position 80 have been studied in fibroblasts from a homozygous familial hypercholesterolaemic subject (MB) and in monkey COS cells transfected with the mutant cDNA. Receptors containing the Glu-80-->Lys mutation were processed more slowly than the normal protein and only approx. 50% reached the surface as the mature...

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PMID: 7734445
DOI: 10.1016/0005-2760(94)00243-r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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