A nonsense mutation in the gene encoding 2'-5'-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice.

doi:10.1073/pnas.172195399

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Article

A nonsense mutation in the gene encoding 2'-5'-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 2002

Mashimo Tomoji, Lucas Marianne, Simon-Chazottes Dominique, Frenkiel Marie-Pascale, Montagutelli Xavier, Ceccaldi Pierre-Emmanuel, Deubel Vincent, Guenet Jean-Louis, Despres Philippe

Abstract excerpt

A mouse model has been established to investigate the genetic determinism of host susceptibility to West Nile (WN) virus, a member of the genus flavivirus and family Flaviviridae. Whereas WN virus causes encephalitis and death in most laboratory inbred mouse strains after peripheral inoculation, most strains derived from recently trapped wild mice are completely resistant. The phenotype of...

Topics

2',5'-Oligoadenylate Synthetase
Animals
Animals, Laboratory
Base Sequence
Codon, Nonsense
Crosses, Genetic
DNA Primers
Genetic Predisposition to Disease
Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoenzymes

Mice

Mice, Inbred BALB C

Mice, Inbred C57BL

Mice, Inbred Strains

Molecular Sequence Data

Sequence Alignment

Sequence Homology, Nucleic Acid

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 12186974
DOI: 10.1073/pnas.172195399
PMCID: PMC123253

Provenance

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