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Article

Regulation of double-stranded DNA gap repair by the RAD6 pathway.

DNA repair - 1 Nov 2008

Moertl Simone, Karras Georgios I, Wismüller Tobias, Ahne Fred, Eckardt-Schupp Friederike

Abstract excerpt

The RAD6 pathway allows replication across DNA lesions by either an error-prone or error-free mode. Error-prone replication involves translesion polymerases and requires monoubiquitylation at lysine (K) 164 of PCNA by the Rad6 and Rad18 enzymes. By contrast, the error-free bypass is triggered by modification of PCNA by K63-linked polyubiquitin chains, a reaction that requires in addition to Rad6 and Rad18 the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Radiation

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Source

Identifiers

PMID: 18722556
DOI: 10.1016/j.dnarep.2008.07.016

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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