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Article

Unloaded rat hearts in vivo express a hypertrophic phenotype of cardiac repolarization.

Journal of molecular and cellular cardiology - 1 Nov 2008

Schwoerer Alexander Peter, Melnychenko Ivan, Goltz Diane, Hedinger Nils, Broichhausen Irene, El-Armouche Ali, Eschenhagen Thomas, Volk Tilmann, Ehmke Heimo

Abstract excerpt

Cardiac unloading with left ventricular assist devices is increasingly used to treat patients with severe heart failure. Unloading has been shown to improve systolic and diastolic function, but its impact on the repolarization of left ventricular myocytes is not known. Unloaded hearts exhibit similar patterns of gene expression as hearts subjected to an increased hemodynamic load. We therefore hypothesized that...

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Source

Identifiers

PMID: 18721926
DOI: 10.1016/j.yjmcc.2008.02.271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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