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The strange case of Drp1 in autophagy: Jekyll and Hyde?

15 Feb 2022

Abstract excerpt

There is a debate regarding the function of Drp1, a GTPase involved in mitochondrial fission, during the elimination of mitochondria by autophagy. A number of experiments indicate that Drp1 is needed to eliminate mitochondria during mitophagy, either by reducing the mitochondrial size or by providing a noncanonical mitophagy function. Yet, other convincing experimental results support the conclusion that Drp1 is...

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Share to Autophagy in Disease and Therapy
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PMID: 35166388
DOI: 10.1002/bies.202100271

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