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Article

Developmental and epigenetic regulation of the human TLR3 gene.

Molecular immunology - 1 Nov 2008

Porrás Analia, Kozar Sarah, Russanova Valya, Salpea Paraskevi, Hirai Tazuko, Sammons Nicholas, Mittal Pooja, Kim Ji Young, Ozato Keiko, Romero Roberto, Howard Bruce H

Abstract excerpt

The receptor encoded by the human TLR3 gene recognizes double-strand RNAs (dsRNAs) associated with viral infection. TLR3 expression is strongly activated upon differentiation of monocytes to dendritic cells, and can be further stimulated by the dsRNA analog polyinosine:polycytosine (PI:C). We report evidence for developmental regulation of the TLR3 gene. In dendritic cells derived from cord blood, both...

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Source

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Identifiers

PMID: 18715647
DOI: 10.1016/j.molimm.2008.06.030
PMCID: PMC6287275

Genes

TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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