Article
Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM.
Oncogene - 4 Dec 2008
Wickenden J A, Jin H, Johnson M, Gillings A S, Newson C, Austin M, Chell S D, Balmanno K, Pritchard C A, Cook S J
Abstract excerpt
The RAF-mitogen-activated protein kinase kinase 1/2-extracellular signal-regulated kinase 1/2 (RAF-MEK1/2-ERK1/2) pathway is activated in many human tumours and can protect cells against growth factor deprivation; however, most such studies have relied upon overexpression of RAF or MEK constructs...
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